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Creatine Kinase-MB (activity)

SI UNITS (recommended)

CONVENTIONAL UNITS

Synonym

CKMB

Units of measurement

nkat/l, µkat/l, nmol/(s•L), µmol/(s•L), U/L, IU/L, µmol/(min•L), µmol/(h•L), µmol/(h•mL)

Creatine kinase (CK) appears as three isoenzymes which are dimers composed of two types of monomer subunits. The isoenzymes comprise all three combinations of monomers, M (for skeletal muscle derived) and B (for brain derived), as represented by the notations MM, MB, and BB.

Many organs contain CK, but the distribution of isoenzymes is different in each one. Skeletal muscle is very rich in the MM isoenzyme, while brain, stomach, intestine, bladder, and lung contain primarily the BB isoenzyme. The MB isoenzyme has been found in appreciable amounts (15‐20 %) only in myocardial tissue. Therefore, total serum CK activity is elevated in a number of diseases. This lack of specificity limits its diagnostic value. However, the striking difference in the CK isoenzyme patterns from different organs has made CK one of the most useful enzymes for diagnostic purposes in acute myocardial infarction. CK‐MB appears in serum reflecting its unique presence in myocardial tissue. It is in supporting the diagnosis of suspected myocardial infarction that serial determinations of CK isoenzymes find their most frequent application in the clinical laboratory.

SI units Conversion Calculator. Convert Creatine Kinase-MB (activity) level to nkat/l, µkat/l, nmol/(s•L), µmol/(s•L), U/L, IU/L, µmol/(min•L), µmol/(h•L), µmol/(h•mL) . Clinical laboratory units online conversion from conventional or traditional units to Si units. Table of conversion factors for Creatine Kinase-MB (activity) unit conversion to nkat/l, µkat/l, nmol/(s•L), µmol/(s•L), U/L, IU/L, µmol/(min•L), µmol/(h•L), µmol/(h•mL) .

Last updated: February 16, 2025

Created by: Dr. Rajesh Moganti

Reviewed by : Medical Review Board

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